Biography

Anton Sculean is professor and chairman of the Department of Periodontology at the University of Bern in Switzerland. He qualified in 1990 at the Semmelweis University in Budapest, Hungary and has received his postgraduate training at the Universities Münster, Germany and Royal Dental College Aarhus, Denmark. He received his habilitation at the University of Saarland, Homburg, Germany. Professor Sculean has been a recipient of many research awards, among others the Anthony Rizzo Award of the Periodontal Research Group of the International Association for Dental Research (IADR), and the IADR/Straumann Award in Regenerative Periodontal Medicine. He received honorary doctorates (Dr. h.c.) from the Semmelweis University in Budapest, Hungary and from the Victor Babes University in Timisoara, Romania. He has been the author of more than 160 publications in peer reviewed journals and is on the editorial board of more than 10 dental journals. Professor Sculean served from 2009-2010 as president of the Periodontal Research Group of the IADR and is currently president of the Swiss Society of Periodontology. His current research interests include periodontal wound healing, regenerative and plastic-esthetic periodontal therapy, treatment of peri-implantitis, antibiotic and antiseptic therapies, laser treatments and oral biofilms.

Aims

Advances in cell and molecular biology have contributed to increased understanding of wound healing of various tissues, and revealed a great complexity of processes involved. In general, the outcome of wound healing can be characterized either as repair, i.e. scar tissue formation that differs in form and/or function from the original tissues, or regeneration, i.e. form and function of the lost tissues are restored. A large body of evidence has established that polypeptide growth and differentiation factors, enamel matrix proteins, barrier membranes, certain bone grafts or various combinations thereof may support periodontal wound healing/regeneration creating an environment conducive to and/or immediately inducing de novo tissue formation. Moreover, it is now clear that reconstructive periodontal procedures can only be successful if patient related factors and biologically driven surgical approaches, aiming to enhance wound stability are considered.

Objectives

 The presentation will provide an overview on the biologic background, surgical considerations and clinical decision tree of using various biomaterials in reconstructive periodontal surgery for intrabony, furcation and recession defects. Finally, future perspectives will be presented on upcoming indications such as the use of enamel matrix derivative for treating horizontal types of defects and the combination of various collagen substrates and enamel matrix derivative to maximize healing outcomes in recession defects.

Biography

Daniel Rothamel is a graduate of the Heinrich-Heine University of Duesseldorf, Germany, and received his Dr. med. dent. with the thesis “Establishing a new method for quantification of tooth hypersensitivity". He was trained in oral surgery and also obtained the Dr. med with his thesis on “Biocompatibility, biodegradation and angiogenetic aspects of native and cross-linked collagen membranes”. From 2002-2007 he worked as a Research Associate at the Department of Oral Surgery (Prof. Dr. J. Becker) at the Heinrich-Heine University in Duesseldorf, Germany. In 2005, he volunteered at the Clinic of Plastic and Reconstructive Surgery in Sankhu, Kathmandu, Nepal before he went in 2007 to Australia to start a post-doc position at the Department of Oral Pathology and Molecular Research, Westmead Hospital, University of Sydney, Australia (granted by DAAD). In 2008, Daniel Rothamel moved back to Germany to work as a Research Associate in the Department of Oral and Maxillofacial Plastic Surgery (Prof. Dr.Dr. J. Zoeller), University of Cologne, Germany and received his PhD on “Reconstruction of jaw defects using artificial and autogenous bone blocks in combination with growth factors”. Daniel Rothamel is best known for his research interest in guided bone regeneration, implant surfaces, collagen membranes, bone substitute materials, and growth factors.

Aims

One of the most challenging procedures in dental implantology is the predictable and safe regeneration of bone and soft tissue defects. Although autogenous bone is still considered being the golden standard, different biomaterials such as bone substitutes and membranes have shown predictable results in augmentation procedures of the alveolar process. Whereas the regeneration of smaller defects inside the ridge contour may be supported by transmembraneous angioselectivity of the applied membranes, extended defects require volume-stable bone substitute materials and long-lasting barriers. Native porcine pericardium has shown favourable results, based on its multi-layered collagen structure. Moreover, available bone substitutes differ significantly in terms of biochemical aspects, influencing the volume stability, speed of bone formation, graft remodelling and patient´s acceptance. Also the quality of the recipient site, the osteogenicity of the graft and the selected healing time are affecting the predictability of the regeneration outcome.

In addition to bone augmentation biomaterials, specific collagen matrices have been established for soft tissue augmentation procedures, including gingiva thickening, vestibuloplasty and recession coverage. In contrast to the patient´s own soft tissue, the use of biomaterials is not accompanied by donor site morbidity.

Objectives

This presentation will detail selection rules of different collagen matrices and different bone graft materials that fit to the indication, the defect´s shape and to the patient's preconditions in order to achieve the best regeneration outcome. Based on clinical examples new treatment options of prevalent clinical indications like socket preservation that arise from the availability of novel collagen soft tissue grafts will be presented.

Biography

David L. Cochran is a graduate of the University of Virginia and received his D.D.S., M.S. and Ph.D. in Biochemistry from the Medical College of Virginia (MCV). He was trained in Periodontology at the Harvard School of Dental Medicine where he also obtained a second Master‘s degree. He recently received an Honorary Doctorate from the University of Bern in Switzerland. Dr. Cochran is currently Professor and Chairman of the Department of Periodontics at The University of Texas Health Science Center at San Antonio, Dental School. Prior to his appointment at San Antonio, Dr. Cochran was Director of Postgraduate Periodontics at MCV. Dr. Cochran is a member of many professional dental organizations and is a Diplomate of the American Board of Periodontology. He is a fellow of the American College of Dentistry and the International College of Dentistry. Dr. Cochran has published numerous scientific articles and abstracts on various periodontal, biochemistry, and implant topics. He has received awards for his research work at both the national and international levels. Dr. Cochran is an active basic science and clinical researcher who has received funding from both the NIH-NIDCR and private industry.

Aims

Enamel matrix proteins have been clinically used for more than 2 decades and have been documented by vast clinical and preclinical research. Despite the broad biologic potential of enamel matrix proteins to stimulate various cell and tissue types into regenerative and tissue forming patterns, the potential of this component class has been so far only fully explored for the successful treatment of periodontal indications. Recent advances in the research on enamel matrix proteins as a mixture and as partial fractions of the mixture, show that besides inducing periodontal regeneration, enamel matrix proteins stimulate important processes for the formation, maturation and, regeneration of bone, such as the stimulation of osteoblasts and stem cells and the promotion of angiogenesis. With these properties in mind enamel matrix proteins can per se be classified as promising candidates to promote bone growth and bone maturation as part of clinical bone augmentation procedures in periodontology and, importantly in implantology.

Objectives

This presentation introduces Straumann®Osteogain as a new biologic solution that has been developed and optimized for the mixing with bone graft materials and collagen substrates to stimulate bone formation as part of regenerative bone augmentation procedures. It introduces the product concept and rationale, its components and its biological properties to stimulate various physiological activities that are clinically relevant for various bone augmentation procedures.